The hospital was originally built in commemoration of the visit of the Prince of Wales in 1875 and was named King Albert Edward Hospital. Foundation stone was laid by Sir James Fergusson, then the governor of Bombay on 9 March 1881. This was possible with the blessings of the regional ruler Chhatrapati Shahu. This project was completed in 1881. The hospital underwent many changes after Shahu returned from England and offered free treatment to everyone. In 1946 the hospital was renamed to Chhatrapati Pramilatai Raje Hospital in the honour of Chhatrapati Pramilatai Raje, the daughter in law of the royal family of Kolhapur. In the year 2000, the hospital was officially affiliated to the newly established Rajarshee Chhatrapati Shahu Maharaj Government Medical College
